Pharmacology MCQs 10 questions.

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1. which enzyme combination is involved in ergosterol biosynthesis? 

A) Lanosterol 14alpha demethylase and Squalene epoxidase 

B) Lanosterol epoxidase and Squalene16alpha demethylase 

C) Lanosterol epoxidase and Squalene14alpha demethylase 

D) Lanosterol 16alpha demethylase and Squalene epoxidase 

2. which of the following is not true about ?-1,3-glucans?

A) They are small polymers of UDP-glucose (a nucleotide sugar)

B) They are synthesized by ?-1,3-glucan synthase 

C) They form a fibrous network on the inner surface of the cell wall 

D) They make up 50 ? 60% of the dry weight of the fungal cell wall 

3. The mode of action of Polyenes involve: 

A) Loss of membrane integrity and influx of Ca+

B) Inhibition of reproductive function

C) binds to ergosterol

D) Destruction of pore-like molecular aggregates 

4. Which of these is not a Polyene?

A) Terbinafine 

B) Nystatin 

C) Amphotericin B 

D) None

5. What adverse effects are associated with Amphotericin B?

A) Allergic reactions and Reversible renal impairment on accumulation and Hepatotoxicity

B) Allergic reactions and Nephrotoxicity

C) Reversible renal impairment on accumulation Nephrotoxicity and Hepatotoxicity 

D) Allergic reactions Hepatotoxicity and Fungal infection, and Superficial and invasive candidiasis 

6. What is an Allylamines mode of action?

A) Inhibit ergosterol synthesis via Lanosterol epoxidase 

B) Inhibit ergosterol synthesis via Squalene 14alpha demethylase 

C) Inhibit ergosterol synthesis via Squalene epoxidase 

D) Inhibit ergosterol synthesis via Lanosterol 14alpha demethylase 

7. Which of the following is an example of an Allylamine?

A) Terbinafine 

B) Amphotericin B 

C) Nystatin 

D) Fluconazole

8. Allylamines have poor activity against:

A) Cryptococcus spp

B) Dermatophytes 

C) Aspergillus spp. 

D) Candida spp 

9. What is the mode of action in Echinocandins?

A) Inhibition of protein synthesis

B) Inhibition of ?-1,3-glucan synthase

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C) Formation of pore-like molecular aggregates 

D) Inhibit ergosterol synthesis 

10. Which of the following is true of 5-fluorocytosines mechanism of action?

A) it inhibits DNA synthesis 

B) it is converted into 5-fluorouracil which is incorporated into fungal RNA 

C) it inhibits protein synthesis 

D) ALL of the above

References:

Nursing Standards

Nursing and Midwifery Board of Australia. (2018). Code of conduct for midwives. https://www.nursingmidwiferyboard.gov.au/Codes-Guidelines-Statements/Professional-standards.aspx

Clinical Guidelines

Guideline Adaption Committee. (2016). Clinical practice guidelines and principles of care for people with dementia. NHMRC Partnership Centre for Dealing with Cognitive and Related Function Decline in Older People. https://cdpc.sydney.edu.au/wp-content/uploads/2019/06/CDPC-Dementia-Guidelines_WEB.pdf

Living Guideline

Stroke Foundation. (2022). Australian and New Zealand living clinical guidelines for stroke management – chapter 1 of 8: Pre-hospital care. https://app.magicapp.org/#/guideline/NnV76E

Evidence-based practice

BMJ Best Practice

Goldfarb, S., & Josephson, M. (2020). Cystic fibrosis. BMJ Best Practice. https://bestpractice.bmj.com/

Schub, T., & Cabrera, G. (2018). Bites: Head lice [Evidence-based care sheet]. Cinahl Information Systems. https://www.ebscohost.com

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JBI: Evidence summary

Swe, K. K. (2022). Blood glucose levels: Self-monitoring [Evidence summary]. JBI EBP Database. https://jbi.global

JBI: Best practice information sheet

Bellman, S. (2022). Experiences of living with juvenile idiopathic arthritis [Best practice information sheet]. JBI EBP Database, 24(1), 1-4.

Cochrane Database of Systematic Reviews

Srijithesh, P. R., Aghoram, R., Goel, A., & Dhanya, J. (2019). Positional therapy for obstructive sleep apnoea. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD010990.pub2

Drug Information

Codeine. (2023, January). In Australian medicines handbook. Retrieved February 2, 2023, from https://amhonline.amh.net.au

Colorado State University. (2011). Why assign WID tasks? http://wac.colostate.edu/intro/com6a1.cfm

Dartmouth Writing Program. (2005). Writing in the social sciences. http://www.dartmouth.edu/~writing/materials/student/soc_sciences/write.shtml

Rutherford, M. (2008). Standardized nursing language: What does it mean for nursing practice? [Abstract]. Online Journal of Issues in Nursing, 13(1). http://ojin.nursingworld.org/MainMenuCategories/ThePracticeofProfessionalNursing/Health-IT/StandardizedNursingLanguage.html

Wagner, D. (n.d.). Why writing matters in nursing. https://www.svsu.edu/nursing/programs/bsn/programrequirements/whywritingmatters/

Writing in nursing: Examples. (n.d.). http://www.technorhetoric.net/7.2/sectionone/inman/examples.html

Perth Children’s Hospital. (2022, April). Appendicitis [Emergency Department Guidelines]. Child and Adolescent Health Service. https://www.pch.health.wa.gov.au/For-health-professionals/Emergency-Department-Guidelines/Appendicitis

Department of Health. (n.d.). Who is being active in Western Australia? https://ww2.health.wa.gov.au/Articles/U_Z/Who-is-being-active-in-Western-Australia

Donaldson, L. (Ed.). (2017, May 1). Healthier, fairer, safer: The global health journey 2007-2017. World Health Organisation. https://www.who.int/publications/i/item/9789241512367

NCBI Bookshelf

Rodriguez Ziccardi, M., Goyal, G., & Maani, C. V. (2020, August 10). Atrial flutter. In Statpearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK540985/

Royal Perth Hospital. (2016). Procedural management: Pre and post (24-48 hours) NPS. Canvas. https://courses.ecu.edu.au

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