Immune Responses, health and medicine homework help
Description
Abnormal immune responses can trigger a range of autoimmune diseases, in
which an individuals immune system is attacking normal tissues in the
body. Well-known examples of autoimmune diseases are type 1 diabetes
mellitus, lupus, and multiple sclerosis.
Ideally, one would like to harness the immune system to attack abnormal
substances or tissues like cancer, while sparing the normal (unaffected)
tissue. Many tumor cells produce antigens (proteins) that theoretically
ought to trigger an immune response: that is, ones immune system ought
to recognize cancer cells as somehow foreign or abnormal, and
thereafter eliminate these cells from the body. The field of cancer
immunotherapy is actively pursuing this study.
Tumor antigens may also be useful for diagnostic tests; high levels of
tumor antigens could be taken as markers or indicators of cancer. In
this assignment, you will be examining levels of tumor-associated
antigens (TAAs) as determined from immunoassays (i.e., biochemical tests
that measure the concentrations of the tumor-associated antigens in
serum samples).
Having Trouble Meeting Your Deadline?
Get your assignment on Immune Responses, health and medicine homework help completed on time. avoid delay and – ORDER NOW
- Download the Excel file MHA610_assignment_3_data.xls, and open it.
- The spreadsheet contains data on 250 individuals: 90 normal
individuals from San Diego (the controls), and 160 individuals from
Korea and China, all of whom were diagnosed with hepatocellular
carcinoma (HCC).- Serum samples were taken from the controls and from the
cases at time of diagnosis of HCC. Levels of a panel of 12
tumor-associated antigens (TAAs) were assessed via immunoassays in all
individuals;- The levels are given in the columns with headings Ab14,
HCC1, IMP1, KOC, MDM2, NPM1, P16, P53, P90, RaIA, and Survivin. (These
are the designations of the 12 TAAs, all of which were thought to be
potentially predictive of cancer.)
- The levels are given in the columns with headings Ab14,
- Serum samples were taken from the controls and from the
- The underlying question is whether we can effectively
discriminate between the cases and controls on the basis of the levels
of these TAAs. This is sometimes termed a classification problem in the
statistics and biostatistics literature: we wish to classify individuals
as normal or cancer patients on the basis of their TAA levels. - We will examine these data in Statdisk. Use the MHA610_Week 3_Assignment_Data.CSV file to upload this information into Statdisk.
- If you choose the latter option, Start Statdisk, then choose
File>Open and select the .csv file you created (unless you changed
the name, it ought to be MHA610_assignment_3_data.csv) - Check the box that specifies the data contains column titles
or headers, select Comma separated for how the data are delimited,
click finish, and the dataset will have been successfully imported into
Statdisk. - NOTE: you may want to read through the remainder of the
assignment first, before proceeding with this step. This may save you
some work afterwards!
- If you choose the latter option, Start Statdisk, then choose
- Note that Statdisk operates on columns of data, and that both
cases and controls are contained in each column of TAA levels. It will
be necessary to separate the cases and controls for further analyses.
This can be accomplished either by copying within Statdisk or by
reverting to the original Excel workbook, copying in Excel, exporting as
a .csv file, and then importing into Statdisk. (Dont say you werent
warned!) - Explain if you would characterize any or all of the TAA levels
as approximately normally distributed for the controls and for the
cases.- Provide plots and statistics in support of your conclusions.
- Explain if any of the TAAs are useful for discriminating between the cases and controls.
- Provide plots and statistics in support of your conclusions.
- All writing assignments should be at least 250-500 words in APA format supported by scholarly sources.
BONUS. In the above, we pooled all cases together.
Summarize whether you think this is legitimate or whether the levels of
any of the TAAs appear to differ significantly between the cases from
China and the cases from Korea. Provide evidence in support of your
conclusion.
References:
Nursing Standards
Nursing and Midwifery Board of Australia. (2018). Code of conduct for midwives. https://www.nursingmidwiferyboard.gov.au/Codes-Guidelines-Statements/Professional-standards.aspx
Clinical Guidelines
Guideline Adaption Committee. (2016). Clinical practice guidelines and principles of care for people with dementia. NHMRC Partnership Centre for Dealing with Cognitive and Related Function Decline in Older People. https://cdpc.sydney.edu.au/wp-content/uploads/2019/06/CDPC-Dementia-Guidelines_WEB.pdf
Living Guideline
Stroke Foundation. (2022). Australian and New Zealand living clinical guidelines for stroke management – chapter 1 of 8: Pre-hospital care. https://app.magicapp.org/#/guideline/NnV76E
Evidence-based practice
BMJ Best Practice
Goldfarb, S., & Josephson, M. (2020). Cystic fibrosis. BMJ Best Practice. https://bestpractice.bmj.com/
Schub, T., & Cabrera, G. (2018). Bites: Head lice [Evidence-based care sheet]. Cinahl Information Systems. https://www.ebscohost.com
Beyea, S. C., & Slattery, M. J. (2006). Evidence-based practice in nursing: A guide to successful implementation. http://www.hcmarketplace.com/supplemental/3737_browse.pdf
JBI: Evidence summary
Swe, K. K. (2022). Blood glucose levels: Self-monitoring [Evidence summary]. JBI EBP Database. https://jbi.global
JBI: Best practice information sheet
Bellman, S. (2022). Experiences of living with juvenile idiopathic arthritis [Best practice information sheet]. JBI EBP Database, 24(1), 1-4.
Cochrane Database of Systematic Reviews
Srijithesh, P. R., Aghoram, R., Goel, A., & Dhanya, J. (2019). Positional therapy for obstructive sleep apnoea. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD010990.pub2
Drug Information
Codeine. (2023, January). In Australian medicines handbook. Retrieved February 2, 2023, from https://amhonline.amh.net.au
Colorado State University. (2011). Why assign WID tasks? http://wac.colostate.edu/intro/com6a1.cfm
Dartmouth Writing Program. (2005). Writing in the social sciences. http://www.dartmouth.edu/~writing/materials/student/soc_sciences/write.shtml
Rutherford, M. (2008). Standardized nursing language: What does it mean for nursing practice? [Abstract]. Online Journal of Issues in Nursing, 13(1). http://ojin.nursingworld.org/MainMenuCategories/ThePracticeofProfessionalNursing/Health-IT/StandardizedNursingLanguage.html
Wagner, D. (n.d.). Why writing matters in nursing. https://www.svsu.edu/nursing/programs/bsn/programrequirements/whywritingmatters/
Writing in nursing: Examples. (n.d.). http://www.technorhetoric.net/7.2/sectionone/inman/examples.html
Perth Children’s Hospital. (2022, April). Appendicitis [Emergency Department Guidelines]. Child and Adolescent Health Service. https://www.pch.health.wa.gov.au/For-health-professionals/Emergency-Department-Guidelines/Appendicitis
Department of Health. (n.d.). Who is being active in Western Australia? https://ww2.health.wa.gov.au/Articles/U_Z/Who-is-being-active-in-Western-Australia
Donaldson, L. (Ed.). (2017, May 1). Healthier, fairer, safer: The global health journey 2007-2017. World Health Organisation. https://www.who.int/publications/i/item/9789241512367
NCBI Bookshelf
Rodriguez Ziccardi, M., Goyal, G., & Maani, C. V. (2020, August 10). Atrial flutter. In Statpearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK540985/
Royal Perth Hospital. (2016). Procedural management: Pre and post (24-48 hours) NPS. Canvas. https://courses.ecu.edu.au
Explanation & Answer
Our website has a team of professional writers who can help you write any of your homework. They will write your papers from scratch. We also have a team of editors just to make sure all papers are of HIGH QUALITY & PLAGIARISM FREE. To make an Order you only need to click Order Now and we will direct you to our Order Page at Litessays. Then fill Our Order Form with all your assignment instructions. Select your deadline and pay for your paper. You will get it few hours before your set deadline.
Fill in all the assignment paper details that are required in the order form with the standard information being the page count, deadline, academic level and type of paper. It is advisable to have this information at hand so that you can quickly fill in the necessary information needed in the form for the essay writer to be immediately assigned to your writing project. Make payment for the custom essay order to enable us to assign a suitable writer to your order. Payments are made through Paypal on a secured billing page. Finally, sit back and relax.